Synapses Fight Over Glutamate Receptor 1

Synapses fight over glutamate receptor 1.

Ephrin-B3 regulates glutamate receptor signaling at hippocampal synapses.

B-ephrin-EphB receptor signaling modulates NMDA receptors by inducing tyrosine phosphorylation of NR2 subunits. Ephrins and EphB RTKs are localized to postsynaptic compartments in the CA1, and therefore potentially interact in a non-canonical cis- configuration. However, it is not known whether cis- configured receptor-ligand signaling is utilized by this class of RTKs, and whether this might i...

Glutamate receptor plasticity at excitatory synapses in the brain.

1. Synapse plasticity, defined as an activity dependent change in the strength of synapses, was first described in 1973 and, since those seminal experiments were reported, the field of synapse plasticity has expanded into one of the most widely studied areas in neuroscience. 2. Significant effort has been focused on determining the expression mechanisms of the changes in synapse strength. The p...

Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma.

Recently, several laboratories have started to investigate the involvement of glutamate signaling in cancer. In previous studies, we reported on a transgenic mouse model that develops melanoma spontaneously. Subsequent studies in these mice identified that the aberrant expression of metabotropic glutamate receptor 1 (GRM1) in melanocytes played a critical role in the onset of melanoma. Confirma...

Glutamate Transporter Function at Excitatory Synapses